William Bradford, over at Intelligently Sequenced, talks a lot about the evidence of design from cellular DNA repair mechanisms. The genomes of modern cells rely for their integrity on incredibly complicated methods of error-detection and repair. Focussing ID criticism here highlights a fundamental weakness in darwinian origin-of-life scenarios: In order for natural selection to improve a self-reproducing molecule, it must have a mostly reliable method of reproducing itself. Otherwise fit individuals would not be able to transfer their fitness to their descendants.

As we now know, it cannot just be taken for granted that a primitive cell (or even a pool of replicating rna) without repair mechanisms  could maintain its genetic information with enough accuracy to survive, let alone ensure that the descendants of fit individuals were likely to retain their parent's fitness advantage. This is a major obstacle to abiogenesis (as if spontaneously generating self-reproducing molecules wasn't hard enough :-).